Invitrogen™ Csk Monoclonal Antibody (CSK-04)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA544005

Catalog No. PIMA544005

Description

This antibody reacts with Csk (C-terminal Src kinase), a 50 kDa intracellular non-receptor protein tyrosine kinase. Immunoprecipitation: The immunosorbent (CSK-04 antibody covalently bound to beads) immunoprecipitants Csk from cell lysates.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).

Specifications

• Antigen: Csk
• Classification: Monoclonal
• Concentration: 5.1 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P41240, P41241
• Gene Symbols: CSK
• Immunogen: Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunoprecipitation, Western Blot, Immunocytochemistry
• Clone: CSK-04
• Conjugate: Unconjugated
• Gene: CSK
• Gene Alias: AW212630; CSK; CSK, non-receptor tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; C-terminal Src kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 12988, 1445
• Content And Storage: 4°C, do not freeze
• Form: Liquid

Safety and Handling

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