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Invitrogen™ Csk Monoclonal Antibody (CSK-04)
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Catalog No. PIMA544005
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100 μL
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PIMA544005 100 μL
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Catalog No. PIMA544005 Supplier Invitrogen™ Supplier No. MA544005
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Description

Mouse Monoclonal Antibody

This antibody reacts with Csk (C-terminal Src kinase), a 50 kDa intracellular non-receptor protein tyrosine kinase. Immunoprecipitation: The immunosorbent (CSK-04 antibody covalently bound to beads) immunoprecipitants Csk from cell lysates.

CSK is a tyrosine kinase that has been shown to downregulate the activity of SRC oncoprotein through phosphorylation of its carboxy terminus. Since cell transformation by SRC is caused by various mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene. CSK plays an important role in the regulation of cell growth, differentiation, migration, and immune responses. CSK phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases including LCK, SRC, HCK, FYN, LYN, CSK, and YES1. CSK is expressed ubiquitously as a protein of approximately 50 KDa in cytosol, but a fraction distributes to lipid rafts due to interaction with the lipid raft-associated protein PAG (Csk-binding protein).
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Specifications

Antigen Csk
Applications Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone CSK-04
Concentration 5.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene CSK
Gene Accession No. P41240, P41241
Gene Alias AW212630; CSK; CSK, non-receptor tyrosine kinase; C-SRC kinase; c-src tyrosine kinase; C-terminal Src kinase; MGC117393; p50CSK; protein-tyrosine kinase (CSK); protein-tyrosine kinase CYL; Protein-tyrosine kinase MPK-2; Tyrosine-protein kinase CSK
Gene Symbols CSK
Host Species Mouse
Immunogen Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12988, 1445
Target Species Human, Mouse
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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