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CSN2 Rabbit anti-Human, Mouse, Polyclonal, Bethyl Laboratories Non-distribution product as customer accommodation.

Rabbit Polyclonal Antibody

Manufacturer:  Bethyl Laboratories, IncSupplier Diversity Partner A300027A

Catalog No. 50-155-6759


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Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Based on 100% sequence identity, this antibody is predicted to react with Rat, Zebrafish and X. laevis

Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
Specifications

Specifications

CSN2
Polyclonal
Unconjugated
COPS2
liquid
COPS2
Between 1 and 50
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry, Western Blot
1 mg/ml
phosphate, tris citrate with 0.09% sodium azide; pH 7-8
P61201, P61202
ALIEN, CSN2, SGN2, TRIP15
Rabbit
IgG
100 μl
4° C
Primary
12848, 9318
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