Invitrogen™ CSN7b Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5113385

Catalog No. PIPA5113385

Description

CSN7b Polyclonal Antibody for Western Blot, ICC/IF, IHC (P), ELISA

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Specifications

• Antigen: CSN7b
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: COPS7B
• Gene Alias: Arabidopsis; COP9 (constitutive photomorphogenic) homolog, subunit 7b; COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana); COP9 complex S7b; COP9 constitutive photomorphogenic homolog subunit 7B; COP9 signalosome complex subunit 7b; COP9 signalosome subunit 7B; Cops7b; Csn7b; D1Wsu66e; E130114M23; JAB1-containing signalosome subunit 7b; SGN7b; signalosome subunit 7b
• Host Species: Rabbit
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 26895, 64708
• Content And Storage: -20°C or -80°C if preferred
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 3 mg/mL
• Formulation: PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
• Gene Accession No.: Q8BV13, Q9H9Q2
• Gene Symbols: COPS7B
• Immunogen: Recombinant Human COP9 signalosome complex subunit 7b protein (1-157AA).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov