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Invitrogen™ CSN7b Polyclonal Antibody
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Catalog No. PIPA5103080
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Quantity:
100 μL
Catalog No. Quantity
PIPA5103080 100 μL
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Catalog No. PIPA5103080

Supplier: Invitrogen™ PA5103080

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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total COPS7B.

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CSN7b
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene COPS7B
Gene Accession No. Q8BV13, Q9H9Q2
Gene Alias Arabidopsis; COP9 (constitutive photomorphogenic) homolog, subunit 7b; COP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana); COP9 complex S7b; COP9 constitutive photomorphogenic homolog subunit 7B; COP9 signalosome complex subunit 7b; COP9 signalosome subunit 7B; Cops7b; Csn7b; D1Wsu66e; E130114M23; JAB1-containing signalosome subunit 7b; SGN7b; signalosome subunit 7b
Gene Symbols COPS7B
Host Species Rabbit
Immunogen A synthesized peptide derived from human COPS7B(Accession Q9H9Q2), corresponding to amino acid residues D179-Q229.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26895, 64708
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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