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CSN7b Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501981459
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50-198-1459 100 μL
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Catalog No. 50-198-1459 Supplier Bioss Supplier No. BS11540R
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Description

Rabbit Polyclonal Antibody

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.

Specifications

Antigen CSN7b
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene COPS7B
Gene Accession No. Q9H9Q2
Gene Alias Arabidopsis; COP9 constitutive photomorphogenic homolog subunit 7B; COP9 signalosome complex subunit 7b; COP9 signalosome subunit 7B; COPS7B; CSN7B; JAB1-containing signalosome subunit 7b; SGN7b; signalosome subunit 7b
Gene Symbols COPS7B
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human CSN7b.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 64708
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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