Invitrogen™ CST1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5121012

Catalog No. PIPA5121012

Description

Positive test controls include: A-431, A-549, BT-474, THP-1. The target is usually found in the following locations: Secreted. Immunogen sequence: AWSPKEEDRI IPGGIYNADL NDEWVQRALH FAISEYNKAT KDDYYRRPLR VLRARQQTVG GVNYFFDVEV GRTICTKSQP NLDTCAFHEQ PELQKKQLCS FEIYEVPWEN RRSLVKSRCQ ES.

The cystatin superfamily is a well-established family of cysteine protease inhibitors. Cystatins A and B (type 1) are mainly intracellular; cystatins C, D, E/M, F, G, S, SN and SA cystatins are extracellular (type 2); and the kininogens are type 3 cystatins which are intravascular proteins. All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, and some also inhibit legumain family enzymes. Cystatin SA, cystatin S and cystatin SN are found primarily in saliva. Cystatin S and SN can also be expressed in tears, urine and seminal fluid. Cystatin C is a related protein which is expressed in brain, thymus, ovary, epididymis and vas deferens. Cystatin D protects against proteinases in the oral cavity, while Cystatin E/M and F moderate the inhibition of cathepsin proteins. The fetuins, part of the cystatin superfamily, are secretable proteins that influence osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors and the response to systemic inflammation. High molecular weight kininogen (Kininogen HC) and low molecular weight kininogen (Kininogen LC) have varied roles, though they both inhibit the thrombin- and plasmin-induced aggregation of thrombocytes.

Specifications

• Antigen: CST1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CST1
• Gene Alias: 1810034E21Rik; alcadein alpha; alcadein-alpha; alc-alpha; calsyntenin 1; calsyntenin-1; Clstn1; Cs1; CST1; Cst-1; Cstn1; C-terminal fragment 1-alpha; CTF1-alpha; Cystain-SA-I; cystatin 1; cystatin SA-I; cystatin SN; cystatin-1; Cystatin-SN; cysteine proteinase inhibitor, type 2 family; Kiaa0911; SAlc-alpha; Salivary cystatin-SA-1; Soluble Alc-alpha
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1469
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 3.75 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P01037
• Gene Symbols: CST1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 20-141 of human CST1 (NP_001889.2).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG