Invitrogen™ CTCF Monoclonal Antibody (G.758.4)

Catalog No.	Quantity
PIMA511187	100 μL

Catalog No. PIMA511187 Supplier Invitrogen™ Supplier No. MA511187

Description

Rabbit Monoclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with BORIS.

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.

Specifications

• Antigen: CTCF
• Applications: ChIP Assay, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
• Classification: Monoclonal
• Clone: G.758.4
• Concentration: 91 μg/mL
• Conjugate: Unconjugated
• Formulation: 0.01M HEPES with 0.15M NaCl, 100μg/mL BSA, 50% glycerol and <0.02% sodium azide; pH 7.5
• Gene: CTCF
• Gene Accession No.: P49711, Q61164, Q9R1D1
• Gene Alias: 11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); Ctcf; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)
• Gene Symbols: CTCF
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to the carboxy terminus of the human CTCF protein.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10664, 13018, 83726
• Target Species: Human, Mouse, Monkey, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG