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Invitrogen™ CTCF Polyclonal Antibody
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Catalog No. PIPA517143
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100 μL
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Catalog No. Quantity
PIPA517143 100 μL
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Catalog No. PIPA517143 Supplier Invitrogen™ Supplier No. PA517143
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Description

Rabbit Polyclonal Antibody

It is not recommended to aliquot this antibody. This antibody is not cross-reactive with BORIS.

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTCF
Applications ChIP Assay, Immunoprecipitation, Western Blot, RNA Immunoprecipitation, Immunocytochemistry
Classification Polyclonal
Concentration 14 μg/mL
Conjugate Unconjugated
Formulation 0.01M HEPES with 50% glycerol, 100μg/mL BSA, 0.15M NaCl and no preservative; pH 7.5
Gene CTCF
Gene Accession No. P49711, Q61164, Q9R1D1
Gene Alias 11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); Ctcf; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)
Gene Symbols CTCF
Host Species Rabbit
Immunogen Synthetic peptide corresponding to the carboxy terminus of the human CTCF protein.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10664, 13018, 83726
Target Species Human, Mouse, Monkey, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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