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Invitrogen™ CTCF Polyclonal Antibody
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Catalog No. PIPA5143083
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100 μg
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PIPA5143083 100 μg
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Catalog No. PIPA5143083 Supplier Invitrogen™ Supplier No. PA5143083
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Description

Goat Polyclonal Antibody

Additional Information: This antibody is expected to recognize reported isoform 1 (NP_006556.1) only. This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:4,000.

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTCF
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene CTCF
Gene Accession No. P49711
Gene Alias 11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); Ctcf; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)
Gene Symbols CTCF
Host Species Goat
Immunogen Peptide with sequence C-KKSKLRYTEEGKD.
Purification Method Ammonium Sulfate Precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10664
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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