CTCF Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-172-6709	Proteintech Group Inc 109151AP150UL	150 μL

Description

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms′ tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

Specifications

• Antigen: CTCF
• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: P49711, Q61164, Q9R1D1
• Gene ID (Entrez): 10664, 13018, 83726
• Immunogen: CTCF Fusion Protein Ag1340
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: CTCF

• Concentration: 0.18 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
• Gene Alias: 11 zinc finger protein, CCCTC binding factor, CTCF, CTCFL paralog, Transcriptional repressor CTCF
• Gene Symbols: CTCF
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody