CTCF Recombinant Rabbit Monoclonal Antibody, AbFlex™, Active Motif™

Catalog No.	Quantity
50-199-3800	10 μg
50-199-3799	100 μg

Catalog No. 50-199-3800 Supplier Active Motif Supplier No. 91286

Description

Rabbit Recombinant Monoclonal Antibody

Transcriptional factor CTCF is a ubiquitously expressed 11-zinc finger domain containing, DNA-binding nuclear phosphoprotein that is involved in multiple aspects of normal gene regulation including transcriptional repression and activation, gene silencing, chromatin insulation and regulation of imprinted sites. CTCF uses different combinations of ZF domains and interacts with the CCCTC motif on the DNA. It can bind to HAT- and HDAC-containing complexes thereby influencing transcriptional activation or repression respectively. It is a multifunctional protein involved in the transactivation of APPB gene, silencing of c-myc gene, and insulation of human beta-globin and DMI myotonic dystrophy locus and imprinting control of IGF2 and H19 regions. CTCF has also been shown to regulate the transcription of Pax6 and IRAK2 promoter thereby opening a therapeutic avenue. Mutations in this gene have been associated with invasive breast cancers, prostate cancers and Wilms' tumors.

Specifications

• Antigen: CTCF
• Applications: ChIP sequencing (ChIP-seq), Western Blot
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: 140mM HEPES, 32mM sodium acetate with 30% glycerol, 70mM NaCl and 0.035% sodium azide; pH 7.5
• Gene: CTCF
• Gene Accession No.: P49711
• Gene Alias: 11 zinc finger transcriptional repressor; 11-zinc finger protein; AW108038; BOS_17095; CCCTC-binding factor; CCCTC-binding factor (zinc finger protein); CTCF; ctcf protein; CTCFL paralog; im:7152666; MRD21; OTTHUMP00000197610; Transcriptional repressor CTCF; Unknown (protein for IMAGE:8125283)
• Gene Symbols: CTCF
• Host Species: Rabbit
• Immunogen: This antibody was raised against a peptide within human CTCF.
• Purification Method: Protein A
• Quantity: 10 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 10664
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG