Invitrogen™ CTHRC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5106400

Catalog No. PIPA5106400

Description

Antibody detects endogenous levels of total CTHRC1.

The Collagen triple helix repeat-containing protein (CTHRC1) is a glycosylated, secreted protein that is transiently expressed in the arterial wall in response to injury where it is thought to contribute to vascular remodeling by inhibiting collagen expression and deposition and promoting cell migration. CTHRC1 is highly expressed multiple human cancers, including pancreatic cancer where it plays a significant role in the progression and metastasis of the disease by regulating migration and adhesion of tumors cells. CTHRC1 overexpression can also be used as an independent prognostic marker in gastric cancer. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma.

Specifications

• Antigen: CTHRC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Cthrc1
• Gene Alias: 1110014B07Rik; collagen triple helix repeat containing 1; collagen triple helix repeat-containing protein 1; CTHRC1; Protein NMTC1; UNQ762/PRO1550
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 115908, 282836, 68588
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q8CG08, Q96CG8, Q9D1D6
• Gene Symbols: Cthrc1
• Immunogen: A synthesized peptide derived from human CTHRC1(Accession Q96CG8), corresponding to amino acid residues F86-A136.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG