Invitrogen™ CtIP Monoclonal Antibody (19E8)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA123304

Catalog No. MA123304

Description

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.

Specifications

• Antigen: CtIP
• Classification: Monoclonal
• Concentration: 1.0 mg/mL
• Formulation: PBS with 20% glycerol and no preservative; pH 7
• Gene Accession No.: Q80YR6, Q99708
• Gene Symbols: Rbbp8
• Immunogen: Human CtIP.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG1

• Applications: ChIP Assay, Immunoprecipitation, Western Blot, Proximity Ligation Assay, Immunocytochemistry
• Clone: 19E8
• Conjugate: Unconjugated
• Gene: Rbbp8
• Gene Alias: 9930104E21Rik; COM1; CtBP-interacting protein; CtIP; DNA endonuclease RBBP8; JWDS; RB binding protein 8, endonuclease; RBBP8; RBBP-8; retinoblastoma binding protein 8; retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; SCKL2; Sporulation in the absence of SPO11 protein 2 homolog
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 225182, 5932
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid