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Invitrogen™ CTNNA3 Monoclonal Antibody (892_24D2S)
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Catalog No. MA106311
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100 μg
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MA106311 100 μg
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Catalog No. MA106311 Supplier Invitrogen™ Supplier No. MA106311
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Description

Mouse Monoclonal Antibody

MA1-06311 detects alphaT-catenin in human samples. MA1-06311 has sucessfully been used in Western blotting, immunoprecipitation, immunohistochemistry, and immunocytochemistry. By Western blotting, it detects a ~300 kDa protein representing alphaT-catenin. The MA1-06311 immunogen is a synthetic peptide corresponding to residues C V(164) A N K S D L Q K T Y Q K L(177) of the human T-catenin protein with N-term Cys, coupled to KLH.

Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human alphaTcatenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It is proven that alphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins. This indicates that this protein is involved in the formation of specific cell-cell contacts in specific types of muscle cells. The encoded protein has about the same predicted size (100 kDa) as other alpha-catenins to which it shows an overall amino acid identity of 57%. In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was demonstrated by coimmunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not show any cross reaction with alphaE-catenin or alphaNcatenin in western blot analysis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTNNA3
Applications Flow Cytometry, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry
Classification Monoclonal
Clone 892_24D2S
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.09% sodium azide
Gene CTNNA3
Gene Accession No. Q9UI47
Gene Alias 4930429L08Rik; 4933408A16; Alpha T-catenin; Alpha-3 catenin; alpha-catenin-like protein; alpha-T-catenin; ARVD13; Cadherin-associated protein; catenin (cadherin associated protein), alpha 3; catenin (cadherin-associated protein), alpha 3; catenin alpha 3; catenin alpha-3; Catna3; CTNNA3; RGD1559455; RGD1562230; Vr22
Gene Symbols CTNNA3
Host Species Mouse
Immunogen Synthetic peptide to corresponding residues C V(164) A N K S D L Q K T Y Q K L(177) of the human T-catenin protein.
Purification Method Purified
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29119
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG2a
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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