Invitrogen™ CTNNA3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5119851

Catalog No. PIPA5119851

Description

Positive Control: NIH/3T3 cell lysates, Daudi cell lysates, mouse heart tissue. Subcellular Location: Cytoskeleton.

Catenins are proteins that connect cadherin/beta-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alphaT-catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human alphaTcatenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It is proven that alphaT-catenin can functionally restore cell-cell adhesion in colon cancer cells lacking alpha-catenins. This indicates that this protein is involved in the formation of specific cell-cell contacts in specific types of muscle cells. The encoded protein has about the same predicted size (100 kDa) as other alpha-catenins to which it shows an overall amino acid identity of 57%. In cells transfected with alphaT-catenin cDNA, interaction with alpha-catenin was demonstrated by coimmunoprecipitation. The 892_24D2S antibody against alphaT-catenin does not show any cross reaction with alphaE-catenin or alphaNcatenin in western blot analysis.

Specifications

• Antigen: CTNNA3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CTNNA3
• Gene Alias: 4930429L08Rik; 4933408A16; Alpha T-catenin; Alpha-3 catenin; alpha-catenin-like protein; alpha-T-catenin; ARVD13; Cadherin-associated protein; catenin (cadherin associated protein), alpha 3; catenin (cadherin-associated protein), alpha 3; catenin alpha 3; catenin alpha-3; Catna3; CTNNA3; RGD1559455; RGD1562230; Vr22
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 216033, 29119
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
• Gene Accession No.: Q65CL1, Q9UI47
• Gene Symbols: CTNNA3
• Immunogen: Synthetic peptide within human CTNNA3 aa 30-70.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov