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Tocris Bioscience™ CTPI 2

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Quantity:
10 mg
50 mg
Description
CTPI 2 is a selective mitochondrial citrate transporter (SLC25A1) inhibitor with a KD of 3.5 μM. CTPI 2 inhibits the proliferation of H1299 cells in a SLC25A1-dependent manner. It also re-sensitizes T1, T2, and T4 cells to Cisplatin (Cat. No. 2251). CTPI 2 inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC). In high-fat diet fed mice CTPI 2 regulates glycolysis, prevents steatohepatitis and normalizes glucose tolerance and insulin sensitivity. CTPI 2 influences the inflammatory pathway by inhibiting IL-6 and TNFα production and M1 macrophage polarization.
Specifications
Specifications
Chemical Name or Material | 2-[[(4-Chloro-3-nitrophenyl)sulfonyl]amino]benzoic acid |
CAS | 68003-38-3 |
Quantity | 50 mg |
Target | Other Ion Pump/Transporter Inhibitors |
Molecular Formula | C13H9ClN2O6S |
Purity | 98% |
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