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Invitrogen™ CTPS Polyclonal Antibody
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Catalog No. PIPA597640
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100 μg
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PIPA597640 100 μg
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Catalog No. PIPA597640 Supplier Invitrogen™ Supplier No. PA597640
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Description

Rabbit Polyclonal Antibody

CTPS Polyclonal Antibody for Western Blot, IHC (P), ELISA

There are two genes encoding members of a new family of type II integral membrane proteins. Both are ubiquitously expressed, and tissue-specific alternative mRNA initiation and splicing generate at least two major isoforms of each protein, with the smaller isoforms being truncated at the N-terminus. These proteins are called nesprin-l and -2 for nuclear _envelope _spectrin repeat, as they are characterized by the presence of multiple, clustered spectrin repeats, bipartite nuclear localization sequences and a conserved C-terminal, single transmembrane domain. Transient transfection of EGFP-fusion expression constructs demonstrated their localization to the nuclear membrane with a novel C-terminal, TM-domain-containing sequence essential for perinuclear localization. Nesprin-l is developmentally regulated in both smooth and skeletal muscle and is relocalized from the nuclear envelope to the nucleus and cytoplasm during C2Cl2 myoblast differentiation. Nesprins may function as 'dystrophins of the nucleus' to maintain nuclear organization and structura integrity.
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Specifications

Antigen CTPS
Applications ELISA, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 3 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.03% ProClin 300; pH 7.4
Gene CTPS1
Gene Accession No. P17812
Gene Alias cb1040; CTP synthase; CTP synthase 1; CTP synthase 1a; CTP synthase a; CTP synthetase 1; CTPS; ctps1; ctps1a; ctpsa; cytidine 5-prime triphosphate synthetase; cytidine 5'-triphosphate synthase; cytidine 5'-triphosphate synthetase; IMD24; UTP--ammonia ligase 1; wu:fb49e03; wu:fe17b03
Gene Symbols CTPS1
Host Species Rabbit
Immunogen Recombinant Human CTP synthase 1 protein (300-554AA).
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1503
Target Species Human
Content And Storage -20°C or -80°C if preferred
Product Type Antibody
Form Liquid
Isotype IgG
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