Invitrogen™ CTR1 Recombinant Rabbit Monoclonal Antibody (4C10C5)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA542624

Catalog No. PIMA542624

Description

Positive test controls include: 293T, HepG2, A-549, Mouse liver, Mouse kidney, Rat liver. The target is usually found in the following locations: Cell membrane, Multi-pass membrane protein. Immunogen sequence: MDHSHHMGMS YMDSNSTMQP SHHHPTTSAS HSHGGGDSSM MMMPMTFYFG FKNVELLFSG LVINTAGEMA GAFVAVFLLA MFYEGLKIAR ESLLRKSQVS.

The trace metal copper (Cu) plays a crucial role in mammalian cells as a cofactor for many enzymes. Cu-related genetic diseases, such as Menkes disease and Wilson disease, arise from a lack of Cu homeostasis in mammalian cells. CTR1 is a high-affinity copper-uptake protein. The C-terminal domain is similar to the Raf family of protein kinases, but it's first two-thirds encodes a novel protein domain. CTR1 provides the primary avenue for copper uptake in mammalian cells, thereby, affecting Cu homeostasis and embryonic development.

Specifications

• Antigen: CTR1
• Classification: Recombinant Monoclonal
• Concentration: 0.25 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O15431, Q8K211, Q9JK41
• Gene Symbols: SLC31A1
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CTR1/SLC31A1 (NP_0018501).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

• Applications: ELISA, Western Blot
• Clone: 4C10C5
• Conjugate: Unconjugated
• Gene: SLC31A1
• Gene Alias: 4930445G01Rik; AI787263; AU016967; copper transport 1 homolog; copper transporter 1; Copper uptake transporter 1; COPT1; ctr1; ctr-1; hCTR1; high affinity copper uptake protein; high affinity copper uptake protein 1; high-affinity copper uptake protein; liver regeneration-related protein LRRGT00200; LRRGT00200; rCTR1; SLC31A1; slc31a1.L; solute carrier family 13 (sodium/sulphate symporters), member 1; solute carrier family 31 (copper transporter), member 1; solute carrier family 31 (copper transporter), member 1 L homeolog; solute carrier family 31 (copper transporters), member 1; solute carrier family 31 member 1; solute carrier family 31, member 1; Xctr1; XELAEV_18038194mg; zgc:76839
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 1317, 171135, 20529
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

Safety and Handling

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