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Invitrogen™ CTSW Polyclonal Antibody
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Catalog No. PIPA570661
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100 μL
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PIPA570661 100 μL
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Catalog No. PIPA570661 Supplier Invitrogen™ Supplier No. PA570661
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Description

Rabbit Polyclonal Antibody

This target displays homology in the following species: Human: 100%.

Cathepsin W (lymphopain) and cathepsin F comprise a novel subgroup of cathepsin proteases, and are phylogenetically distinct from other human cathepsins. The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81-119 bp. Cathepsin W protein is expressed specifically in CD8+ T lymphocytes. The expression of cathepsin W first occurs during the differentiation of thyrocytes to CD8+ T lymphocytes, just as the thymocytes cease expression of CD4+ receptors. In transfected Cos-7 and HeLa cells, cathepsin W localizes within the rough endoplasmic reticulum. Cathepsin W contains a unique 21 amino acid peptide insertion between the active site histidine and asparagine residues, in addition to a distictive 8-amino acid carboxy-terminal extension. An extended loop struc-ture in the second or beta-sheet domain and an additional disulfide bind are two of several signature features of cathepsin W. Other features of cathepsin W include an additional cysteine, an S2 pocket and an additional residue. Cathepsin W may exist as a dimer with each monomer forming a disulfide bond.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTSW
Applications Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene CTSW
Gene Accession No. P56202
Gene Alias Cathepsin W; Ctsw; lymphopain; LYPN
Gene Symbols CTSW
Host Species Rabbit
Immunogen synthetic peptide directed towards the middle region of human CTSW (aa 95-154).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1521
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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