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Invitrogen™ CTSW Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5144943
Description
Immunogen sequence: EEFGQLYGYR RAAGGVPSMG REIRSEEPEE SVPFSCDWRK VAGAISPIKD QKNCNCCWAM AAAGNIETLW RISFWD Antigen sequence identity: Mouse 53%; Rat 58%.
Cathepsin W (lymphopain) and cathepsin F comprise a novel subgroup of cathepsin proteases, and are phylogenetically distinct from other human cathepsins. The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81-119 bp. Cathepsin W protein is expressed specifically in CD8+ T lymphocytes. The expression of cathepsin W first occurs during the differentiation of thyrocytes to CD8+ T lymphocytes, just as the thymocytes cease expression of CD4+ receptors. In transfected Cos-7 and HeLa cells, cathepsin W localizes within the rough endoplasmic reticulum. Cathepsin W contains a unique 21 amino acid peptide insertion between the active site histidine and asparagine residues, in addition to a distictive 8-amino acid carboxy-terminal extension. An extended loop struc-ture in the second or beta-sheet domain and an additional disulfide bind are two of several signature features of cathepsin W. Other features of cathepsin W include an additional cysteine, an S2 pocket and an additional residue. Cathepsin W may exist as a dimer with each monomer forming a disulfide bond.
Specifications
CTSW | |
Polyclonal | |
Unconjugated | |
CTSW | |
Cathepsin W; Ctsw; lymphopain; LYPN | |
Rabbit | |
Affinity chromatography | |
RUO | |
1521 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid | |
IgG |
Immunohistochemistry (Paraffin) | |
0.2 mg/mL | |
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2 | |
P56202 | |
CTSW | |
Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 97-172. Recombinant protein control fragment (Product #RP-110047). | |
100 μL | |
Primary | |
Human | |
Antibody | |
Liquid |
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