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Invitrogen™ CTSW Polyclonal Antibody
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Catalog No. FEPA5144943
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100 μL
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FEPA5144943 100 μL
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Catalog No. FEPA5144943 Supplier Invitrogen™ Supplier No. PA5144943
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: EEFGQLYGYR RAAGGVPSMG REIRSEEPEE SVPFSCDWRK VAGAISPIKD QKNCNCCWAM AAAGNIETLW RISFWD Antigen sequence identity: Mouse 53%; Rat 58%.

Cathepsin W (lymphopain) and cathepsin F comprise a novel subgroup of cathepsin proteases, and are phylogenetically distinct from other human cathepsins. The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81-119 bp. Cathepsin W protein is expressed specifically in CD8+ T lymphocytes. The expression of cathepsin W first occurs during the differentiation of thyrocytes to CD8+ T lymphocytes, just as the thymocytes cease expression of CD4+ receptors. In transfected Cos-7 and HeLa cells, cathepsin W localizes within the rough endoplasmic reticulum. Cathepsin W contains a unique 21 amino acid peptide insertion between the active site histidine and asparagine residues, in addition to a distictive 8-amino acid carboxy-terminal extension. An extended loop struc-ture in the second or beta-sheet domain and an additional disulfide bind are two of several signature features of cathepsin W. Other features of cathepsin W include an additional cysteine, an S2 pocket and an additional residue. Cathepsin W may exist as a dimer with each monomer forming a disulfide bond.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CTSW
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CTSW
Gene Accession No. P56202
Gene Alias Cathepsin W; Ctsw; lymphopain; LYPN
Gene Symbols CTSW
Host Species Rabbit
Immunogen Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence. Antigen range: 97-172. Recombinant protein control fragment (Product #RP-110047).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 1521
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Format Liquid
Isotype IgG
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