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Invitrogen™ CTSW Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA570661

Catalog No. PIPA570661


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Description

Description

This target displays homology in the following species: Human: 100%.

Cathepsin W (lymphopain) and cathepsin F comprise a novel subgroup of cathepsin proteases, and are phylogenetically distinct from other human cathepsins. The cathepsin W gene maps to chromosome 11q13.1 and contains ten exons with introns ranging from 81-119 bp. Cathepsin W protein is expressed specifically in CD8+ T lymphocytes. The expression of cathepsin W first occurs during the differentiation of thyrocytes to CD8+ T lymphocytes, just as the thymocytes cease expression of CD4+ receptors. In transfected Cos-7 and HeLa cells, cathepsin W localizes within the rough endoplasmic reticulum. Cathepsin W contains a unique 21 amino acid peptide insertion between the active site histidine and asparagine residues, in addition to a distictive 8-amino acid carboxy-terminal extension. An extended loop struc-ture in the second or beta-sheet domain and an additional disulfide bind are two of several signature features of cathepsin W. Other features of cathepsin W include an additional cysteine, an S2 pocket and an additional residue. Cathepsin W may exist as a dimer with each monomer forming a disulfide bond.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CTSW
Polyclonal
Unconjugated
CTSW
Cathepsin W; Ctsw; lymphopain; LYPN
Rabbit
Affinity chromatography
RUO
1521
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot
0.5 mg/mL
PBS with 2% sucrose and 0.09% sodium azide
P56202
CTSW
synthetic peptide directed towards the middle region of human CTSW (aa 95-154).
100 μL
Primary
Human
Antibody
IgG
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