CUEDC2 Mouse anti-Human, Clone: OTI2H6, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF800815

Catalog No. 50-166-5331

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, ∽40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.

Specifications

• Antigen: CUEDC2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: CUEDC2
• Gene Alias: C10orf66, bA18I14.5
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 79004
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Western Blot
• Clone: OTI2H6
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9H467
• Gene Symbols: CUEDC2
• Immunogen: Full length human recombit protein of human CUEDC2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1