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Invitrogen™ CUEDC2 Polyclonal Antibody
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Catalog No. PIPA583341
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100 μL
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PIPA583341 100 μL
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Catalog No. PIPA583341 Supplier Invitrogen™ Supplier No. PA583341
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DLSGLDEVIF SYVLGVLEDL GPSGPSEENF DMEAFTEMME AYVPGFAHIP RGTIGDMMQK LSGQLSDARN KENLQPQSSG VQGQVPI Highest antigen sequence indentity to the following orthologs: Rat - 75%, Mouse - 95%.

The CUE (coupling of ubiquitin conjugation to endoplasmic reticulum degradation) domain is an evolutionarily conserved, approximately 40 amino acid monoubiquitin-binding domain that mediates intramolecular monoubiquitylation. CUE domains are present in eukaryotic proteins that are involved in ubiquitination and protein trafficking pathways and may be required for ubiquitination of the proteins in which they are found. CUEDC2 (CUE domain-containing protein 2) was found through a yeast two-hybrid screening as a protein that interacts with the progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway. CUEDC2 also decreases the sumoylation of PR. CUEDC2 has also been found to interact with IKK-alpha and IKK-beta and decrease the activation of NF-kappa-B by decreasing the activation of IKK.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CUEDC2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene CUEDC2
Gene Accession No. Q9H467
Gene Alias 3010002G01Rik; bA18I14.5; C10orf66; CUE domain containing 2; CUE domain-containing protein 2; CUEDC2; HOYS6; Unknown (protein for MGC:128745)
Gene Symbols CUEDC2
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human CUEDC2. Recombinant protein control fragment (Product #RP-97041).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79004
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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