Invitrogen™ CUG-BP Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536277

Catalog No. PIPA536277

Description

This antibody detects endogenous protein at a molecular weight of 50 and 54 kDa. Purity is >95% by SDS-PAGE.

CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.

Specifications

• Antigen: CUG-BP
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CELF2
• Gene Alias: 1600010O03Rik; 50 kDa nuclear polyadenylated RNA-binding protein; AA407467; B230218O03; B230345P09Rik; Brain protein F41; Brunol2; BRUNOL3; bruno-like 2; bruno-like protein 2; Bruno-like protein 3; C88023; Celf1; CELF-1; Celf2; CELF-2; CUG RNA-binding protein; CUG triplet repeat RNA-binding protein 1; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 1; CUG triplet repeat, RNA binding protein 2; CUG triplet repeat, RNA-binding protein 1; CUGBP; CUG-BP; CUG-BP- and ETR-3-like factor 1; CUG-BP- and ETR-3-like factor 2; Cugbp- and Etr3-like factor 2; CUGBP Elav-like family member 1; CUGBP Elav-like family member 2; CUGBP, Elav-like family member 1; CUGBP, Elav-like family member 2; Cugbp1; CUG-BP1; Cugbp2; CUG-BP2; D230046B21Rik; D2Wsu101e; deadenylation factor CUG-BP; Deadenylation factor EDEN-BP; EDEN-BP; EDEN-BP homolog; ELAV-type RNA-binding protein 3; embryo deadenylation element binding protein; embryo deadenylation element-binding protein homolog; ETR3; ETR-3; hNab50; hNAPOR; mETR-3; mNapor; NAB50; Napor; Napor-2; Neuroblastoma apoptosis-related RNA-binding protein; nuclear polyadenylated RNA-binding protein, 50-kD; RNA-binding protein BRUNOL-2; RNA-binding protein Brunol3; RNA-binding protein BRUNOL-3; rNapor
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10658, 10659, 13046, 14007, 29428, 362160
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: O95319, P28659, Q4QQT3, Q792H5, Q92879, Q9Z0H4
• Gene Symbols: CELF1, CELF2
• Immunogen: Synthetic peptide corresponding to amino acids 62-115 of human CUG-BP1/2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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