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Invitrogen™ CUG-BP2 Polyclonal Antibody
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Catalog No. PIPA530401
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100 μL
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PIPA530401 100 μL
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Catalog No. PIPA530401 Supplier Invitrogen™ Supplier No. PA530401
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: NT2D1, IMR32, MCF-7. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (97%), Xenopus laevis (99%), Chicken (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CUG-BP2
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.74 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene CELF2
Gene Accession No. O95319, Q792H5, Q9Z0H4
Gene Alias B230218O03; B230345P09Rik; BRUNOL3; Bruno-like protein 3; C88023; cb906; CELF 2; Celf2; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; Cugbp- and Etr3-like factor 2; CUGBP Elav-like family member 2; CUGBP, Elav-like family member 2; Cugbp2; CUG-BP2; cugbp2 protein; D230046B21Rik; elav-type ribonucleoprotein-3; elav-type RNA-binding protein 3; ETR3; ETR-3; fj87b07; hNAPOR; mETR-3; mNapor; NAPOR; napor protein isoform; napor protein long isoform; napor protein short isoform; Napor-2; neur; neuroblastoma apoptosis-related RNA-binding protein; RNA-binding protein; RNA-binding protein Brunol3; RNA-binding protein BRUNOL-3; rNapor; RP23-124P7.1; wu:fj87b07
Gene Symbols CELF2
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human CUGBP2. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10659, 14007, 29428
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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