Invitrogen™ CUG-BP2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA530401

Catalog No. PIPA530401

Description

Recommended positive controls: NT2D1, IMR32, MCF-7. Predicted reactivity: Mouse (100%), Rat (100%), Zebrafish (97%), Xenopus laevis (99%), Chicken (100%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CUG-BP1 and CUG-BP2 are proteins that bind specifically to (CUG)8 oligonucleotides in vitro. While CUG-BP1 has the major binding activity in normal cells, nuclear CUG-BP2 binding activity increases in DM cells. Both CUG-BP1 and CUG-BP2 are isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. CUG-BP1, an RNA CUG triplet repeat binding protein, regulates splicing and translation of various RNAs. Expansion of RNA CUG repeats in the DMPK in DM is associated with alterations in binding activity of CUG-BP1 as well as alterations in the translation of the C/EBPb transcription factor. CUG-BP1 is an important regulator of initiation from different AUG codons of C/EBPb mRNA.

Specifications

• Antigen: CUG-BP2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CELF2
• Gene Alias: B230218O03; B230345P09Rik; BRUNOL3; Bruno-like protein 3; C88023; cb906; CELF 2; Celf2; CELF-2; CUG triplet repeat RNA-binding protein 2; CUG triplet repeat, RNA binding protein 2; CUG-BP- and ETR-3-like factor 2; Cugbp- and Etr3-like factor 2; CUGBP Elav-like family member 2; CUGBP, Elav-like family member 2; Cugbp2; CUG-BP2; cugbp2 protein; D230046B21Rik; elav-type ribonucleoprotein-3; elav-type RNA-binding protein 3; ETR3; ETR-3; fj87b07; hNAPOR; mETR-3; mNapor; NAPOR; napor protein isoform; napor protein long isoform; napor protein short isoform; Napor-2; neur; neuroblastoma apoptosis-related RNA-binding protein; RNA-binding protein; RNA-binding protein Brunol3; RNA-binding protein BRUNOL-3; rNapor; RP23-124P7.1; wu:fj87b07
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10659, 14007, 29428
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.74 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: O95319, Q792H5, Q9Z0H4
• Gene Symbols: CELF2
• Immunogen: Recombinant protein encompassing a sequence within the center region of human CUGBP2. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG