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CUGBP1 Mouse anti-Human, Clone: OTI5B8, liquid, TrueMAB™
SDP

Catalog No. 501672092
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50-167-2092 100 μL
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Catalog No. 50-167-2092 Supplier OriGene Supplier No. TA500951
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Description

Mouse Monoclonal Antibody

Myotonic dystrophy (MD) is an autosomal domit neuromuscular disease that is associated with a (CTG)n repeat expansion in the 3′-untranslated region of the myotonin protein kinase (Mt-PK) gene. A (CUG) n oligonucleotides triplet repeat pre-mRNA/mRNA binding protein may play an important role in DM pathogenesis. HeLa cell protein, CUG-BP1, has been purified based upon its ability to bind specifically to (CUG) 8 oligonucleotides in vitro. CUG-BP1 is the major (CUG) 8 binding activity in normal cells. CUG-BP1 has been identified as isoforms of a novel heterogeneous nuclear ribonucleoprotein (hnRNP), hNab50. The CUG-BP/hNab50 protein is localized predomitly in the nucleus and is associated with polyadenylated RNAs in vivo. In vitro RNA-binding/photocrosslinking studies demonstrate that CUG-BP/hNab50 binds to RNAs containing the Mt-PK 3-UTR. The (CUG) n repeat region in Mt-PK mRNA is a binding site for CUG-BP/hNab50 in vivo, and triplet repeat expansion leads to sequestration of this hnRNP on mutant Mt-PK transcripts.

Specifications

Antigen CUGBP1
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI5B8
Concentration 0.99 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CELF1
Gene Accession No. Q92879
Gene Alias BRUNOL2, CUG-BP, CUGBP, CUGBP1, EDEN-BP, NAB50, NAPOR, hNab50
Gene Symbols CELF1
Host Species Mouse
Immunogen Full length human recombit protein of human CUGBP1 produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10658
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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