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CUL4B Mouse anti-Canine, Human, Mouse, Clone: OTI1C4, liquid, TrueMAB™
SDP

Catalog No. 501678327
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50-167-8327 100 μL
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Catalog No. 50-167-8327 Supplier OriGene Supplier No. TA800444
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Description

Mouse Monoclonal Antibody

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition subunit. CUL4B may act within the complex as a scaffold protein, contributing to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Plays a role as part of the E3 ubiquitin-protein ligase complex in polyubiquitination of CDT1, histone H2A, histone H3 and histone H4 in response to radiation-induced DNA damage. Targeted to UV damaged chromatin by DDB2 and may be important for DNA repair and DNA replication. Required for ubiquitination of cyclin E, and consequently, normal G1 cell cycle progression. Regulates the mammalian target-of-rapamycin (mTOR) pathway involved in control of cell growth, size and metabolism. Specific CUL4B regulation of the mTORC1-mediated pathway is dependent upon 26S proteasome function and requires interaction between CUL4B and MLST8.

Specifications

Antigen CUL4B
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Monoclonal
Clone OTI1C4
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene CUL4B
Gene Accession No. A2A432, Q13620
Gene Alias CUL-4B, MRXHF2, MRXS15, MRXSC, SFM2
Gene Symbols CUL4B
Host Species Mouse
Immunogen Human recombit protein fragment corresponding to amino acids 1-300 of human CUL4B produced in E.coli.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 492102, 72584, 8450
Target Species Canine, Human, Mouse
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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