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Invitrogen™ CUL5 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA5114723
Description
Antibody detects endogenous levels of total CUL5.
CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
Specifications
CUL5 | |
Polyclonal | |
Unconjugated | |
CUL5 | |
4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; CUL5; CUL-5; cullin 5; cullin-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); Vacm1; VACM-1; vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein; Vasopressin-activated calcium-mobilizing receptor-1 | |
Rabbit | |
Affinity chromatography | |
RUO | |
64624, 75717, 8065 | |
-20°C | |
Liquid |
Western Blot | |
1 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide | |
Q93034, Q9D5V5, Q9JJ31 | |
CUL5 | |
A synthesized peptide derived from human CUL5(Accession Q93034), corresponding to amino acid residues A375-L425. | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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