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Invitrogen™ CUL5 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5114723

Catalog No. PIPA5114723


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Description

Description

Antibody detects endogenous levels of total CUL5.

CUL5 is a core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. It seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein and may form a cell surface vasopressin receptor.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

CUL5
Polyclonal
Unconjugated
CUL5
4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; CUL5; CUL-5; cullin 5; cullin-5; Cullin-5 (vasopressin-activated calcium-mobilizing receptor-1); Vacm1; VACM-1; vasopressin-activated calcium-mobilizing receptor 1; vasopressin-activated calcium-mobilizing receptor protein; Vasopressin-activated calcium-mobilizing receptor-1
Rabbit
Affinity chromatography
RUO
64624, 75717, 8065
-20°C
Liquid
Western Blot
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide
Q93034, Q9D5V5, Q9JJ31
CUL5
A synthesized peptide derived from human CUL5(Accession Q93034), corresponding to amino acid residues A375-L425.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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