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Invitrogen™ Cullin 2 Polyclonal Antibody
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Catalog No. PIPA5120902
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100 μL
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PIPA5120902 100 μL
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Catalog No. PIPA5120902 Supplier Invitrogen™ Supplier No. PA5120902
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Description

Rabbit Polyclonal Antibody

Positive test controls include: PC-3, K-562, HL-60, 293T, OVCAR3. Immunogen sequence: LEYVERATWN DRFSDIYALC VAYPEPLGER LYTETKIFLE NHVRHLHKRV LESEEQVLVM YHRYWEEYSK GADYMDCLYR YLNTQFIKKN KLTEADLQYG YGGVDMNEPL MEIGELALDM WRKLMVEPLQ AILIRMLLRE IKNDRGGEDP NQKVIHGVIN SFVHVEQYKK KFPLKFYQEI FESPFLTETG EYYKQEASNL LQESNCSQYM EKVLGRLKDE EIRCRKYLHP SSYTKVIHEC QQRMVADHLQ FLHAECHNII RQEKKNDMAN M.

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cullin 2
Applications ELISA, Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.63 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Cul2
Gene Accession No. Q13617
Gene Alias 1300003D18Rik; 4932411N15Rik; AI327301; CUL2; CUL-2; cullin 2; cullin-2; MGC131970; mKIAA4106; OTTHUMP00000019437; testis secretory sperm-binding protein Li 238E
Gene Symbols Cul2
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 40-310 of human Cullin 2 (NP_001185708.1).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8453
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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