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Invitrogen™ Cullin 2 Recombinant Rabbit Monoclonal Antibody (JG72-31)
Rabbit Recombinant Monoclonal Antibody
Supplier: Invitrogen™ MA545001
This item is not returnable.
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Description
Cullin 2 Recombinant Monoclonal Antibody for Western Blot, IHC (P), IP
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt].
Specifications
Cullin 2 | |
Recombinant Monoclonal | |
1 mg/mL | |
TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4 | |
Q13617, Q9D4H8 | |
Cul2 | |
Synthetic peptide within N-terminal Human Cullin 2 . | |
100 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot | |
JG72-31 | |
Unconjugated | |
Cul2 | |
1300003D18Rik; 4932411N15Rik; AI327301; CUL2; CUL-2; cullin 2; cullin-2; MGC131970; mKIAA4106; OTTHUMP00000019437; testis secretory sperm-binding protein Li 238E | |
Rabbit | |
Protein A | |
RUO | |
361258, 71745, 8453 | |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
Liquid |
Safety and Handling
WARNING: Cancer - www.P65Warnings.ca.gov
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