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Invitrogen™ Cullin 2 Recombinant Rabbit Monoclonal Antibody (JG72-31)
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Catalog No. PIMA545001
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100 μL
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PIMA545001 100 μL
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Catalog No. PIMA545001 Supplier Invitrogen™ Supplier No. MA545001
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Description

Rabbit Recombinant Monoclonal Antibody

Cullin 2 Recombinant Monoclonal Antibody for Western Blot, IHC (P), IP

Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. ECS complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:27565346). May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF). [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cullin 2
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Recombinant Monoclonal
Clone JG72-31
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene Cul2
Gene Accession No. Q13617, Q9D4H8
Gene Alias 1300003D18Rik; 4932411N15Rik; AI327301; CUL2; CUL-2; cullin 2; cullin-2; MGC131970; mKIAA4106; OTTHUMP00000019437; testis secretory sperm-binding protein Li 238E
Gene Symbols Cul2
Host Species Rabbit
Immunogen Synthetic peptide within N-terminal Human Cullin 2 .
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 361258, 71745, 8453
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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