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Cullin 4A Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA549716

Catalog No. PA549716


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Description

Description

The antibody detects endogenous level of total Cullin 4A protein.

CUL4a is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9.
Specifications

Specifications

Cullin 4A
Polyclonal
Unconjugated
CUL4A
Liquid
CUL4A
Synthetic peptide corresponding to a region derived from 721-735 amino acids of Human cullin 4A
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
ELISA, Immunohistochemistry (Paraffin), Western Blot
0.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q13619, Q3TCH7
cullin 4A
Rabbit
IgG
100 μL
-20° C, Avoid Freeze/Thaw Cycles
Primary
8451, 99375
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