Invitrogen™ Cullin 9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553421

Catalog No. PIPA553421

Description

Immunogen sequence: REGGIYAVLV CMQEYKTSVL VQQAGLAALK MLAVASSSEI PTFVTGRDSI HSLFDAQMTR EIFASIDSAT RPGSESLLLT VPAAVILMLN TEGCSSAARN GLLLLNLLLC NHHTLGDQII TQELRDTLFR HSGIAPRTEP MP Highest antigen sequence identity to the following orthologs: Mouse - 89%, Rat - 92%.

The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.

Specifications

• Antigen: Cullin 9
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CUL9
• Gene Alias: 1810035I07Rik; CUL9; CUL-9; cullin 9; cullin-9; H7AP1; KIAA0708; mKIAA0708; p53-associated parkin-like cytoplasmic protein; PARC; parkin-like cytoplasmic p53 binding protein; RP3-330M21.2; UbcH7-associated protein 1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 23113
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8IWT3
• Gene Symbols: CUL9
• Immunogen: Recombinant protein corresponding to Human Cullin 9. Recombinant protein control fragment (Product #RP-91066).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov