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Invitrogen™ Cullin 9 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520277

Catalog No. PIPA520277


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Description

Description

A suggested positive control is Daudi cell lysate. PA5-20277 can be used with blocking peptide PEP-0354.

The continued localization of p53 to the nucleus is essential for its function as a tumor suppressor. PARC, a large, Parkin-like ubiquitin ligase has recently been identified as a cytoplasmic anchor protein in p53-associated protein complexes. In the absence of stress, PARC inactivation results in nuclear localization of p53 and activation of p53-dependent apoptosis, while overexpression of this protein promoted cytoplasmic sequestration of p53. Surprisingly, PARC knockout mice were viable and exhibited no obvious phenotype, suggesting that other proteins, such as the highly related cullin family of E3 ubiquitin ligases, may perform similar functions in the absence of PARC. Additionally, it has been suggested that p53 binding to PARC may serve to control PARC function.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Cullin 9
Polyclonal
Unconjugated
CUL9
1810035I07Rik; CUL9; CUL-9; cullin 9; cullin-9; H7AP1; KIAA0708; mKIAA0708; p53-associated parkin-like cytoplasmic protein; PARC; parkin-like cytoplasmic p53 binding protein; RP3-330M21.2; UbcH7-associated protein 1
Rabbit
Antigen Affinity Chromatography
RUO
23113, 78309
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 0.02% sodium azide
Q80TT8, Q8IWT3
CUL9
A 17 amino acid peptide from near the carboxy terminus of human PARC.
100 μg
Primary
Human, Mouse
Antibody
IgG
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