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Cutaneous Lymphocyte Antigen Rat anti-Human, FITC, Clone: HECA-452, BD

Catalog No. BDB561987 Shop All BD Biosciences Products
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BDB555947 100 Tests
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Catalog No. BDB561987 Supplier BD Biosciences Supplier No. 561987

Description

Rat Monoclonal Antibody

The HECA-452 monoclonal antibody specifically reacts with Cutaneous Lymphocyte Associated Antigen (CLA), a carbohydrate domain shared by sialyl Lewis[x] (sLe[x]) and sialyl Lewis[a] (sLe[a]) antigens. It serves as a ligand for selectins including CD62E (E-selectin; ELAM-1). CLA is expressed on high endothelium and on lymphocytes including most T lymphocytes infiltrating cutaneous sites of inflammation. Amongst peripheral blood cells, it is expressed on monocytes and granulocytes and a subset of lymphocytes. The HECA-452 antibody is also reportedly crossreactive with the mouse CLA carbohydrate epitope that is transiently expressed by PSGL-1/CD162 on activated T cells. A number of studies suggest that CLA plays an important role in supporting leucocyte adhesive interactions and migration into extravascular tissues during inflammation.

This antibody is routinely tested by flow cytometric analysis. Other applications were tested at BD Biosciences Pharmingen during antibody development only or reported in the literature.

TRUSTED_SUSTAINABILITY

Specifications

Antigen Cutaneous Lymphocyte Antigen
Applications Flow Cytometry
Classification Monoclonal
Clone HECA-452
Conjugate FITC
Description CLA; PSGL-1; CD162; P-selectin glycoprotein ligand 1; SELPL; SELPLG
Formulation Aqueous buffered solution containing BSA and ≤0.09% sodium azide.
Host Species Rat
Immunogen Lymphocyte-depleted Stromal Preparation of Tonsil
Purification Method Affinity Purified
Quantity 25 Tests
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human, Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgM κ
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For Research Use Only.

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