Invitrogen™ CWC22 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557796

Catalog No. PIPA557796

Description

Immunogen sequence: RNQQTNDRKQ KERRQEHGHQ ETRTERERRS EKHRDQNSRG SNWRDPITKY TSDKDVPSER NNYSRVANDR DQEMHIDLEN KHGDP Highest antigen sequence identity to the following orthologs: Mouse - 46%, Rat - 48%.

Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. [UniProt].

Specifications

• Antigen: CWC22
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CWC22
• Gene Alias: AA684037; AI173004; AL022752; B230213M24; Cwc22; CWC22 homolog, spliceosome-associated protein; CWC22 spliceosome-associated protein; CWC22 spliceosome-associated protein homolog; CWC22 spliceosome-associated protein homolog (S. cerevisiae); EIF4GL; fSAPb; functional spliceosome-associated protein b; KIAA1604; mKIAA1604; NCM; Nucampholin homolog; pre-mRNA-splicing factor CWC22 homolog; RGD1565385
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 57703
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.4 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9HCG8
• Gene Symbols: CWC22
• Immunogen: Recombinant protein corresponding to Human CWC22. Recombinant protein control fragment (Product #RP-96184).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG