Invitrogen™ CWC22 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588996

Catalog No. PIPA588996

Description

Immunogen sequence: LTDELREHLK NTPKVIVAQK PDVEQNKSSP SSSSSASSSS ESDSSDSDSD SSDSSSESSS EESDSSSISS HSSASANDVR KKGHGKTRSK EVDKLIRNQQ TNDRKQKERR QEHGHQETRT ERERRSEKHR DQNSSGSNWR DPITKYTSDK DVPSERNNYS RVANDRDQEM HIDLENKHGD PKKKRGERRN SFSENEKHTH RIKDSENFRR KDRSKSKEMN RKHSGSRSDE DRYQNGAERR WEKSSRYSEQ SRESKKNQDR RREKSPAKQK; Positive Samples: Mouse liver, Mouse testis; Cellular Location: Nucleus, Nucleus speckle.

Required for pre-mRNA splicing as component of the spliceosome (PubMed:12226669, PubMed:11991638, PubMed:22961380, PubMed:28502770, PubMed:28076346, PubMed:29360106, PubMed:29301961). Promotes exon-junction complex (EJC) assembly (PubMed:22959432, PubMed:22961380). Hinders EIF4A3 from non-specifically binding RNA and escorts it to the splicing machinery to promote EJC assembly on mature mRNAs. Through its role in EJC assembly, required for nonsense-mediated mRNA decay. [UniProt].

Specifications

• Antigen: CWC22
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CWC22
• Gene Alias: AA684037; AI173004; AL022752; B230213M24; Cwc22; CWC22 homolog, spliceosome-associated protein; CWC22 spliceosome-associated protein; CWC22 spliceosome-associated protein homolog; CWC22 spliceosome-associated protein homolog (S. cerevisiae); EIF4GL; fSAPb; functional spliceosome-associated protein b; KIAA1604; mKIAA1604; NCM; Nucampholin homolog; pre-mRNA-splicing factor CWC22 homolog; RGD1565385
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 80744
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.04 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8C5N3
• Gene Symbols: CWC22
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 639-908 of human CWC22 (NP_0659941).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG