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Invitrogen™ CWF19L1 Polyclonal Antibody
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Catalog No. PIPA531646
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100 μL
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PIPA531646 100 μL
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Catalog No. PIPA531646 Supplier Invitrogen™ Supplier No. PA531646
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Description

Rabbit Polyclonal Antibody

Recommended positive controls: 293T, Raji. Predicted reactivity: Mouse (91%), Rat (91%), Rhesus Monkey (95%), Chimpanzee (98%), Bovine (92%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

CWF19L1 (CWF19 Like Cell Cycle Control Factor 1) is a gene located on chromosome 10 and encodes a protein involved in the regulation of mRNA splicing and cell cycle control. The protein interacts with key splicing factors within the nucleus, including components of the U5 small nuclear ribonucleoprotein (snRNP) and the pre-mRNA processing factor 19 (PRPF19) complex. CWF19L1 plays a crucial role in the alternative splicing of immune-related genes, thereby influencing the expression levels of cytotoxic molecules and enhancing T-cell cytotoxicity. Pathogenic variants in CWF19L1 have been linked to a rare autosomal recessive form of hereditary ataxia known as SCAR17 (Spinocerebellar Ataxia, Autosomal Recessive 17), characterized by symptoms such as global developmental delay, cerebellar ataxia, pyramidal signs, and seizures. This gene's deficiency disrupts normal mRNA splicing and leads to significant alterations in gene expression, impacting cellular and neurological functions.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CWF19L1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene CWF19L1
Gene Accession No. Q69YN2
Gene Alias 2610528C06Rik; AI854304; AV336991; C19L1; Cwf19l1; CWF19-like 1 cell cycle control; CWF19-like 1, cell cycle control (S. pombe); CWF19-like protein 1; hDrn1; SCAR17
Gene Symbols CWF19L1
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the C-terminus region of human CWF19L1. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55280
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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