Invitrogen™ CWF19L1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA557860

Catalog No. PIPA557860

Description

Immunogen sequence: IELLEIPEHS DIKQIAQPGA AYFYVELDTG EKLFHRIKKN FPLQFGREVL ASEAILNVPD KSDWRQCQIS KEDEETLARR FRKDFEPYDF TLDD Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

CWF19L1 (CWF19 Like Cell Cycle Control Factor 1) is a gene located on chromosome 10 and encodes a protein involved in the regulation of mRNA splicing and cell cycle control. The protein interacts with key splicing factors within the nucleus, including components of the U5 small nuclear ribonucleoprotein (snRNP) and the pre-mRNA processing factor 19 (PRPF19) complex. CWF19L1 plays a crucial role in the alternative splicing of immune-related genes, thereby influencing the expression levels of cytotoxic molecules and enhancing T-cell cytotoxicity. Pathogenic variants in CWF19L1 have been linked to a rare autosomal recessive form of hereditary ataxia known as SCAR17 (Spinocerebellar Ataxia, Autosomal Recessive 17), characterized by symptoms such as global developmental delay, cerebellar ataxia, pyramidal signs, and seizures. This gene's deficiency disrupts normal mRNA splicing and leads to significant alterations in gene expression, impacting cellular and neurological functions.

Specifications

• Antigen: CWF19L1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CWF19L1
• Gene Alias: 2610528C06Rik; AI854304; AV336991; C19L1; Cwf19l1; CWF19-like 1 cell cycle control; CWF19-like 1, cell cycle control (S. pombe); CWF19-like protein 1; hDrn1; SCAR17
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 55280, 72502
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q69YN2, Q8CI33
• Gene Symbols: CWF19L1
• Immunogen: Recombinant protein corresponding to Human CWF19L1. Recombinant protein control fragment (Product #RP-97025).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG