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Invitrogen™ CX3CL1 Polyclonal Antibody
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Catalog No. PIPA547728
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100 μg
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PIPA547728 100 μg
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Catalog No. PIPA547728 Supplier Invitrogen™ Supplier No. PA547728
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Description

Goat Polyclonal Antibody

In Western blots, less than 5% cross-reactivity with recombinant human (rh) Eotaxin is observed. This antibody neutralizes the biological activity of rhCX3CL1 and rmCX3CL1 with similar effectiveness. Reconstitute at 0.2 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

Chemokines are a family of proteins associated with the trafficking of leukocytes in immune surveillance and inflammatory cell recruitment. They are classified based on the positions of key cysteine residues. CX3CL1 is a CX3C chemokine known to induce adhesion and migration of leukocytes mediated by a membrane-bound and soluble form respectively. Recent experiments have shown that CX3CL1 can suppress the production of nitrous oxide, interleukin-6, and TNF-a in activated microglia and neuronal cells, suggesting that it may act as an intrinsic inhibitor against neurotoxicity by activated microglia. Its receptor, CX3CR1, also functions as a co-receptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by CX3CL1.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CX3CL1
Applications ELISA, Immunohistochemistry (Frozen), Neutralization, Western Blot
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene Cx3cl1
Gene Accession No. O55145
Gene Alias A-152E5.2; AB030188; ABCD-3; Acc1; AI848747; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C; CX3C membrane-anchored chemokine; C-X3-C motif chemokine 1; C-X3-C motif chemokine ligand 1; Cx3cl1; CXC3; CXC3C; D8Bwg0439e; Fkn; Fractalkine; neurotactin; NTN; NTT; Processed fractalkine; SCYD1; small inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine, neurotactin); small inducible cytokine subfamily D (Cys-X3-Cys), member-1; small inducible cytokine subfamily D, 1; small-inducible cytokine D1
Gene Symbols Cx3cl1
Host Species Goat
Immunogen E. coli-derived recombinant rat CX3CL1/Fractalkine Gln25-Gly100.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 89808
Target Species Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG
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