Invitrogen™ CXCL17 Monoclonal Antibody (510614)

Rat Monoclonal Antibody

Supplier:  Invitrogen™ MA524222

Catalog No. PIMA524222

Description

This antibody detects recombinant mouse (rm) CXCL17/VCC-1 in direct ELISAs and Western blots. In direct ELISAs, 50% cross-reactivity with recombinant human CXCL17 is observed/VCC-1. Reconstitute at 0.5 mg/mL in sterile PBS.

CXCL17 is a chemokine that acts as chemoattractant for monocytes, macrophages and dendritic cells. In particular, CXCL17 is a mucosal chemokine that attracts dendritic cells and blood monocytes to the lungs. CXCL17 plays a role in angiogenesis and possibly in the development of tumors. Further, CXCL17 acts as an anti-inflammatory in the stomach and may play a role in the innate defense against infections. CXCL17 also activates the C-X-C chemokine receptor GPR35 to induce a rapid and transient rise in the level of intracellular calcium ions. 4-Cys CXCL17 seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. Diseases associated with CXCL17 dysfunction include cholera.

Specifications

• Antigen: CXCL17
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: Q5UW37
• Gene Symbols: CXCL17
• Immunogen: E. coli-derived recombinant mouse CXCL17/VCC-1 Ser31-Leu119.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Mouse
• Product Type: Antibody
• Isotype: IgG2b

• Applications: Western Blot
• Clone: 510614
• Conjugate: Unconjugated
• Gene: CXCL17
• Gene Alias: 13.6 kDa protein; 13.6-kDa protein; 4-Cys CXCL17; 6-Cys CXCL17; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; chemokine (C-X-C motif) ligand 17; CXC; CXC motif chemokine; C-X-C motif chemokine 17; C-X-C motif chemokine ligand 17; CXCL; CXCL17; Dcip1; Dendritic cell and monocyte chemokine-like protein; DMC; UNQ473; UNQ473/PRO842; Vcc1; VCC-1; VEGF coregulated chemokine 1; VEGF co-regulated chemokine 1
• Host Species: Rat
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 232983
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized