Invitrogen™ CXCR3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA519828

Catalog No. PIPA519828

Description

This antibody is predicted to react with mouse, rat, cow, dog and pig based on sequence homology.

CD183, also known as CXCR3, is a seven-transmembrane G protein-coupled chemokine receptor that binds CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (I-TAC), which are part of the CXC chemokine subfamily. CD183 plays a crucial role in leukocyte traffic, influencing integrin activation, cytoskeletal changes, and chemotactic migration. It is expressed on NK cells, subsets of T lymphocytes, regulatory T cells (Tregs), and is preferentially found on Th1-polarized cells. CD183 is prominently expressed in effector/memory T cells and T cells in inflamed tissues, contributing to CD4 T cell responses to grafts, as evidenced by compromised allograft rejection in CXCR3 knockout mice. Chemokine binding induces rapid, short-lived cellular responses due to receptor internalization, with responsiveness restored after receptor recycling. Inhibition by Bordetella pertussis toxin suggests coupling with Gi subclass G proteins. The production of IP-10, Mig, and I-TAC in inflammatory lesions indicates CD183 role in recruiting inflammatory cells, making it a target for developing antagonists to treat inflammatory diseases. Multiple transcript variants encoding different isoforms of CD183 have been identified.

Specifications

• Antigen: CXCR3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CXCR3
• Gene Alias: an; C Cmotif chemokine; C X C motif chemokine; CC motif chemokine; CCmotif chemokine; CD182; CD183; chemokine (C-X-C motif) receptor 3; chemokine receptor 3; CKR-L2; Cmkar3; CXC; C-X-C chemokine receptor type 3; CXC motif chemokine; C-X-C motif chemokine receptor 3; Cxcr3; CXC-R3; CXCR-3; G protein-coupled receptor 9; GPR9; Interferon-inducible protein 10 receptor; IP10; IP10 receptor; IP-10 receptor; IP10-R; Mig receptor; MigR; Mig-R
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 2833
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.9 mg/mL
• Formulation: PBS with 1% BSA and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P49682
• Gene Symbols: CXCR3
• Immunogen: Synthetic peptide conjugated to KLH derived from within residues 150 - 250 of Human CXCR3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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