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Cxxc4 Polyclonal Antibody, Active Motif™
SDP

Catalog No. 501993612
Encompass
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50-199-3612 100 μL
50-199-3613 10 μL
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Catalog No. 50-199-3612 Supplier Active Motif Supplier No. 61679
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Description

Rabbit Polyclonal Antibody

CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4 interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.

Specifications

Antigen Cxxc4
Applications Western Blot
Classification Polyclonal
Concentration Lot-Specific
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.035% sodium azide; pH 7.5
Gene CXXC4
Gene Accession No. Q6NXI8, Q9H2H0
Gene Alias 9330210J02Rik; C030003J12Rik; CXXC finger 4; CXXC finger protein 4; Cxxc4; CXXC-type zinc finger protein 4; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); Idax; inhibition of the Dvl and axin complex protein; inhibitor of the Dvl and Axin complex
Gene Symbols CXXC4
Host Species Rabbit
Immunogen This antibody was raised against a peptide within the N-terminal region of mouse Cxxc4.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 319478, 80319
Target Species Human, Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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