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Invitrogen™ CXXC4 Polyclonal Antibody
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Catalog No. PIPA521054
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100 μg
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Catalog No. Quantity
PIPA521054 100 μg
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Catalog No. PIPA521054 Supplier Invitrogen™ Supplier No. PA521054
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Description

Rabbit Polyclonal Antibody

A suggested positive control is human brain tissue lysate. PA5-21054 can be used with blocking peptide PEP-1168.

CXXC4 is zinc finger protein that binds directly to the PDZ domain of DVL1, a protein involved in the Wnt signaling pathway, through its C-terminal region. CXXC4 interaction with DVL1 competes with DVL1-AXIN binding, although the affinity of DVL1 for CXXC4 is lower than that for AXIN. In mouse fibroblasts, CXXC4 suppressed Wnt3a induction of beta-catenin and inhibited Wnt3a-dependent TCF4 activation, suggesting that CXXC4 acts as a negative regulator of the Wnt signaling pathway and functions between DVL and beta-catenin. Recent reports suggest that decreased CXXC4 expression is associated with kidney cancer metastasis, cell proliferation, reduced apoptosis in response to cancer drugs, and upregulation of genes involved with proliferation, invasion and cell survival, suggesting that CXXC4 plays a critical role in tumor progression in kidney cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen CXXC4
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene CXXC4
Gene Accession No. Q6NXI8, Q9EQC9, Q9H2H0
Gene Alias 9330210J02Rik; C030003J12Rik; CXXC finger 4; CXXC finger protein 4; CXXC4; CXXC-type zinc finger protein 4; Dvl-binding protein IDAX (inhibition of the Dvl and Axin complex); Idax; inhibition of the Dvl and axin complex protein; inhibitor of the Dvl and Axin complex
Gene Symbols CXXC4
Host Species Rabbit
Immunogen An 18 amino acid peptide near the amino terminus of human CXXC4.
Purification Method Antigen Affinity Chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 319478, 80319, 83824
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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