Invitrogen™ CYB561D2 Polyclonal Antibody

Catalog No.	Quantity
PIPA518098	100 μg

Catalog No. PIPA518098 Supplier Invitrogen™ Supplier No. PA518098

Description

Goat Polyclonal Antibody

This antibody is predicted to react with bovine, canine, mouse and rat based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.

CYB561D2 (Cytochrome b561 domain-containing protein 2), also known as putative tumor suppressor protein 101F6, is a 222 amino acid highly hydrophobic protein that contains six membrane spanning domains. Localized to endosomes and endoplasmic reticulum of the perinuclear region, CYB561D2 contains 2 heme-binding sites, through which it reduces ferric ions. CYB561D2 is ubiquitously expressed, with highest levels in lung, liver and kidney. Though expression of CYB561D2 is abundant in normal lung bronchial epithileal cells, CYB561D2 is absent in most lung cancers. The gene encoding CYB561D2 maps to human chromosome 3p21.3, a region that is prone to genetic alterations and is associated with frequent and early allele loss in many human cancers. Exogenous expression of CYB561D2 leads to the induction of caspase-independent apoptotic and autophagic pathways, resulting in the synergistic killing of tumor cells. This suggests an important role for CYB561D2 as a therapeutic intervention in cancer treatment.

Specifications

• Antigen: CYB561D2
• Applications: Western Blot
• Classification: Polyclonal
• Concentration: 0.5 mg/mL
• Conjugate: Unconjugated
• Formulation: TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
• Gene: CYB561D2
• Gene Accession No.: O14569
• Gene Alias: 101F6; 101F6 protein; AW049681; CYB561D2; cytochrome b-561 domain containing 2; cytochrome b561 domain-containing protein 2; cytochrome b561 family member D2; cytochrome b561 family, member D2; gene for 101F6 protein; LUCA12.2; OTTHUMP0000021067; OTTHUMP00000210675; OTTHUMP00000210676; Putative tumor suppressor protein 101F6; Transmembrane ascorbate ferrireductase; Tsp10; tumor suppressor, region 10; XXcos-LUCA11.4
• Gene Symbols: CYB561D2
• Host Species: Goat
• Immunogen: Synthetic peptide sequence (VSNAYLYRKRIQP) corresponding to the C-terminus amino acids of CYB561D2 (aa 210-222).
• Purification Method: Ammonium sulfate precipitation
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 11068
• Target Species: Human
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov