Invitrogen™ Cyclin A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA536048

Catalog No. PIPA536048

Description

This antibody detects endogenous protein at a molecular weight of 52 kDa. Purity is >95% by SDS-PAGE.

The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.

Specifications

• Antigen: Cyclin A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: CCNA2
• Gene Alias: AA408589; CCN1; Ccn-1; CCNA; Ccna1; CCNA2; CT146; Cyca; Cyca2; Cyclin A; cyclin A1; cyclin A2; Cyclin A2 (Cyclin A); CyclinA; cyclin-A; CyclinA1; Cyclin-A1; cyclin-A2; testicular tissue protein Li 34
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 114494, 12427, 12428, 295052, 890, 8900
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P20248, P51943, P78396, Q61456, Q6AY13
• Gene Symbols: CCNA1, CCNA2
• Immunogen: Synthetic peptide corresponding to amino acids 220-270 of human Cyclin A.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG