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Cyclin A Polyclonal Antibody, Invitrogen™

Catalog No. PIPA516519
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500 μL
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Catalog No. Quantity
PIPA516519 500 μL
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Catalog No. PIPA516519 Supplier Thermo Scientific Supplier No. PA516519

Description

Rabbit Polyclonal Antibody

PA5-16519 targets Cyclin A in IHC (P), IP, and WB applications and shows reactivity with mouse, Rat, and Human samples. The PA5-16519 immunogen is a synthetic peptide from the C-terminus of human cyclin A.

The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclin A
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene CCNA2
Gene Accession No. P20248, P51943, P78396, Q61456, Q6AY13
Gene Alias AA408589; CCN1; Ccn-1; CCNA; Ccna1; CCNA2; CT146; Cyca; Cyca2; Cyclin A; cyclin A1; cyclin A2; Cyclin A2 (Cyclin A); CyclinA; cyclin-A; CyclinA1; Cyclin-A1; cyclin-A2; testicular tissue protein Li 34
Gene Symbols CCNA1, CCNA2
Host Species Rabbit
Immunogen A synthetic peptide from the C-terminus of human cyclin A
Purification Method Protein A
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114494, 12427, 12428, 295052, 890, 8900
Target Species Human, Mouse, Rat
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG
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