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  6. Epredia™ Lab Vision™ Cyclin E Ab-5, Mouse Monoclonal Antibody

Epredia™ Lab Vision™ Cyclin E Ab-5, Mouse Monoclonal Antibody

Catalog No. MS1060S Shop All Epredia Products
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7 mL
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Catalog No. Quantity Form
MS1060S 1 mL Concentrated
MS1060S0 100 μL Concentrated
MS1060S1 500 μL Concentrated
MS1060R1 1 mL Prediluted
MS1060R7 7 mL Prediluted
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Catalog No. MS1060S Supplier Epredia™ Supplier No. MS1060S

Description

Obtain accurate, reproducible results in immunohistochemistry and immunoprecipitation experiments with Epredia™ Cyclin E Ab-5, Mouse Monoclonal Antibody.

Cyclin E is a regulatory subunit of cdk-2 and controls G1/S transition during the mammalian cell cycle. Multiple isoforms of cyclin E are expressed only in tumors but not in the normal tissues, suggesting a post-transcriptional regulation of cyclin E. In vitro analyses indicated that these truncated variant isoforms of cyclin E are able to phosphorylate histone H1. Alterations in cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Host Species: Mouse

Clone: 13A3

Isotype: IgG2a/κ

Species Reactivity: Human. Others not known.

Epitope: Not determined

Immunogen: Recombinant human cyclin E protein

Molecular Weight: Doublet of 50 kDa and a single band of 42 kDa

Positive Control: SKBR3 and LS174T cells; Breast CA or placenta

Cellular Localization: Nuclear

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Immunoprecipitation (Native and Denatured)

Note:

USA: RUO; Int'l: RUO

Specifications

Antigen Cyclin E Ab-5
Applications Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Monoclonal
Clone 13A3
Conjugate Unconjugated
Host Species Mouse
Immunogen Recombinant human cyclin E protein
Purification Method SKBR3 and LS174T cells, breast CA or placenta
Quantity 1 mL
Regulatory Status RUO
Research Discipline Cell Cycle
Primary or Secondary Primary
Target Species Human
Form Concentrated
Isotype IgG2a κ
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