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Invitrogen™ Cyclin G1 Polyclonal Antibody
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Catalog No. PIPA599163
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100 μL
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PIPA599163 100 μL
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Catalog No. PIPA599163 Supplier Invitrogen™ Supplier No. PA599163
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total Cyclin G.

Cyclins are the regulatory subunits of Cdc2 p34 and related cyclin-dependent kinases (Cdks) which play critical roles in the control of cell cycle progression. The catalytic subunit for cyclin A and B is Cdc2 p34 kinase. The Cdc2- cyclin B complex controls the G2 to M transition whereas Cdc2-cyclin A regulates S phase progression. The G1 to S transition, however, appears to be controlled by the G1 cyclins. Cyclin D1 accumulates during G1 and associates with Cdk2, Cdk4 and Cdk5. Cyclin E and Cdk2 interact during the G1 to S transition. Cyclin G contains a typical N terminal cyclin box and a carboxy terminal domain sequence homologous to the tyrosine phosphorylation site of the epidermal growth factor receptor. Cyclin G expression is induced within 3 hours after growth stimulation and remains elevated with no apparent cell cycle dependency. Cyclin G2 shares 53% amino acid sequence identity with cyclin G1. Peak expression of cyclin G2 is seen in late S phase, as opposed to cyclin G1 expression, which is constitutive.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Cyclin G1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Ccng1
Gene Accession No. P39950, P51945, P51959
Gene Alias AI314029; CCNG; CCNG1; CYCG; CYCG1; cyclin G1; cyclin-G; Cyclin-G1
Gene Symbols Ccng1
Host Species Rabbit
Immunogen A synthesized peptide derived from human CCNG1(Accession P51959), corresponding to amino acid residues R174-I224.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 12450, 25405, 900
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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