Invitrogen™ Cyclin L1 Polyclonal Antibody

Catalog No.	Quantity
PA549750	100 μL

Catalog No. PA549750 Supplier Invitrogen™ Supplier No. PA549750

Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total Cyclin L1 protein.

FUS/TLS was originally described as fused in Sarcoma is actually related to a number of different cellular processes and correlated to several diseases. FUS binds DNA as a single or double strand, and acts as a site for transcription factors to recognize. Since FUS is well-documented to be involved in liposarcoma, lipoma and leukaemia, it is believed that when its normal housekeeping functions related to transcription are disrupted, normal cells become cancerous. Interestingly, FUS is also associated with the fatal neuron disorder amyotrophic lateral sclerosis; interruption of its normal RNA-binding functions leads to incorrect cellular localization and leads to pathologies of the neuron. Thus, FUS regulation of cellular functions is a critical component of maintenance of healthy cells.

Specifications

• Antigen: Cyclin L1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: Ccnl1
• Gene Accession No.: Q52KE7, Q9R1Q2, Q9UK58
• Gene Alias: 2610030E23Rik; ANIA6A; ania-6a; AU018493; BM-001; Ccn1; Ccnl; CCNL1; Cyclin Ania-6a; cyclin L ania-6a; cyclin L gamma; cyclin L1; cyclin-L; Cyclin-L1; LOW QUALITY PROTEIN: cyclin-L1; PRO1073; UNQ530/PRO1073
• Gene Symbols: Ccnl1
• Host Species: Rabbit
• Immunogen: Synthesized peptide derived from human Cyclin-L1.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 114121, 56706, 57018
• Target Species: Human, Mouse, Rat
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG