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Invitrogen™ Cyclin T1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA582177

Catalog No. PIPA582177


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Description

Description

Immunogen sequence: KTSEQTILNM ISQSSSDTTI AGLMSMSTST TSAVPSLPVS EESSSNLTSV EMLPGKRWLS SQPSFKLEPT QGHRTSENLA LTGVDHSLPQ DGSNAFISQK QNSKSVPSAK VSLKEYRAKH AEELAAQKRQ LEN.

This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

Cyclin T1
Polyclonal
Unconjugated
Ccnt1
2810478G24Rik; AI115585; CCNT; CCNT1; CDK9-associated C-type protein; cyclin C-related protein; cyclin T1; cyclin T1b; cyclin-T; cyclin-T1; CycT1; HIVE1; human immunodeficiency virus type 1 (HIV-1) expression (elevated) 1
Rabbit
Antigen Affinity Chromatography
RUO
12455, 315291, 904
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
0.1 mg/mL
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
O60563, Q9QWV9
Ccnt1
Recombinant protein corresponding to Human CCNT1. Recombinant protein control fragment (Product #RP-102511).
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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